414 Influence of filaggrin genotype on regulatory T cells in atopic dermatitis

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

BACKGROUND Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA). Loss-offunction mutations in FLG lead to reduced levels of filaggrin degradation products in the SC. It has recently been suggested that expression of filaggrin may additionally b...

Upregulation of CD47 in Regulatory T Cells in Atopic Dermatitis

PURPOSE Regulatory T (Treg) cells are key modulators in the immune system. Recent studies have shown that atopic dermatitis (AD) patients have higher numbers of Treg cells; however, little is known about the specific phenotype and function of Treg cells in AD. MATERIALS AND METHODS To identify differentially expressed proteins in peripheral induced Treg cells in AD and naturally derived Treg ...

Filaggrin single nucleotide polymorphisms in atopic dermatitis.

Atopic dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin for which no monogenic cause has been identified so far. Meanwhile, the filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease. One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction wa...

Skin barrier in atopic dermatitis: beyond filaggrin*

Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and ph...

Atopic Dermatitis: Possible Roles of Filaggrin in the Development of Atopic Dermatitis